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Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin
However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH
This study demonstrates that the microbiome has a substantial role in the signature and abundance of circulating metabolites in mammalian blood
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